I would do the reverse of :
https://learn.microsoft.com/en-us/exchange/security-and-compliance/smime-exo/configure-smime-exo
If you set the requirements to $false:
https://learn.microsoft.com/en-us/powershell/module/exchange/set-smimeconfig?view=exchange-ps
See what is set:
Get-SmimeConfig
it should disable the clients using it
Also disable client usage if necessary here: