Hi MSGuy-999,
This issue seems to be caused by the Bloomberg add-in. To test and eliminate the possibility that this third-party Excel add-in is causing an Excel save issue, start Excel in safe mode. To do this, follow these steps:
1. Find the shortcut icon for your Office application.
2. Press and hold the CTRL key and double-click the Excel shortcut.
3. Click Yes when a window appears asking if you want to start the application in Safe Mode>Try to save a new Excel file.
If the file saves correctly, a custom add-in is most likely causing the issue.
This can be because of the interactions with the individual user profile under Windows. You can try deactivating the Bloomberg Add-In in Excel and then reinstall the Add-In. You can check this PDF for the steps.
Note: Steps in the link are for Windows 7 but it should be same for Windows 8 and 10.
As you mentioned, installing 64-bit version of Office 2016 resolved the issue for some users.
1. Can you check the Office version of the users whose issue was resolved by installing the 64-bit and compare it with the users who are still facing the issue? To check the version, in Excel, click File>Account > check the exact Office app version, under Product Information, it looks like 16.0.69.65.2066.
2. Since when are you facing the issue? After June update or July?
3. Can you provide us with exact Office 2016 version?
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Thanks,
Neha