I've arrived to the same conclusion about ACPI.sys causing the latency issues with my audio interface. I'm using a top-of-the-line Alienware x17 Dell laptop.
I like @devbobcz 's idea of a native Windows profile to specifically address this issue. I bought a high end Windows gaming laptop thinking the hardware specs would keep up with MacOS stability, but the rabbit hole I've gone down to try to solve this has destroyed my faith in Windows truly being ready for a live DJing or studio workstation environment.