Well, this seems a popular problem.
I´m using Office 2019, Windows 10 updated, and a decent laptop. In the morning I was using PowerPoint and, hours later after this use, all Office programs stopped working. No new installations in the meantime, nothing.
After a full day tinkering and executing all possible solutions found online, now when trying to open any Office program it show the deadly message "operating system is not configured to run this application"
Beforehand (before uninstalling Office with Microsoft´s dedicated tool) after clicking the Word (or any other) icon it showed nothing. No messages, no program opening. But I could see it "running" in the Task Manager.
So I again uninstalled Office 2019, and bought a 2021 Professional Pro. Now I´m enjoying again the "operating system is not configured to run this application" error message.
One of the dozens webites I visited suggested, at the very end of the article, to consider alternatives to Microsoft Office ....
Let´s hope the engineers find a way to fix this annoying, time-consuming problem.
(could be a nice Christmas present ;-)
Regards,
Alberto