We are experiencing this issue somewhere since March 2021. Somewhere around July/August it has gotten worse. We did not directly link it to O365 but issues with Hyper-V Dynamic Memory because we are seeing issue within the VM when it hot swaps memory. After doing some forced updates of O365 in the MonthyEnterprise Channel we started to link it to O365. We are downgrading to version 16.0.14026.20308 and so far we see everything is gotten much more stable. Weird things is we have 100+ VMs some with identical configs (OS+O365 versions) some having issue others having none.
I want to file a Premier Support ticket and since we are Tier 1 CSP see if I can get this escalated to get some more info on this.
If anyone wants to share their ticketnumbers from MSFT I will reference them.